The following is an example of the production of ethyl cellulose by the process of the present invention. If you are not sure if your printer is a postscript printer please refer to your owners manual. The graph bars on the material properties cards further below compare ethyl cellulose. Ethyl cellulose is a widely used excipient in pharmaceutical applications. Ethyl cellulose was grafted with ionic liquids in optimal yields 62. Example an alkalicellulose is prepared by immersing cellulose in a 60% aqueous solution of sodium hydroxide and pressing the impregnated cellulose until the amount of solution remaining contains a quantity of sodium hydroxide corresponding.
Physical structure and thermal behavior of ethylcellulose. It can be prepared by treatment of cellulose with dimethyl sulfate and ethyl chloride in the presence of an alkali. The controlled release folic acidloaded ethyl cellulose microcapsules were prepared by oilinoil emulsion. Us2605328a flexible web coated with an ethyl cellulose. Ethyl cellulose containing less than 4648% of ethoxyl groups is freely soluble in. By ethylene oxide and of alkaline cellulose ether derived. It is widely used it is widely used in cosmetics, cleaning solut ions, and other household pro duct.
Ethyl cellulose is thermoplastic, with a softening point of 140170c and a melting point of 160210c. Chemical names cellulose ethyl ether, ethyl ether of cellulose c. The ethyl cellulose of each grade can in turn form 30 kinds of products according to the differences in the viscosity. Ethylcellulose is a freeflowing, white to light tan powder used in the pharmaceutical and food manufacturing industries. Ethyl cellulose is also used in the food industry as an emulsifier. Ethyl cellulose or ethylcellulose is a derivative of cellulose in which some of the hydroxyl groups on the repeating glucose units are converted into ethyl ether groups. May 24, 2018 ethylcellulose is a freeflowing, white to light tan powder used in the pharmaceutical and food manufacturing industries. It is mainly used as a thinfilm coating material for coating paper, vitamin and medical pills, and for thickeners in cosmetics and in industrial processes.
Chemical properties of ethyl acetate cas 141786 download as pdf file download as excel file download as 2d mole file predict properties. Some properties of ethyl cellulose films sciencedirect. Ethylcellulose ec, an ethyl ether of cellulose, is a freeflowing. The properties of ethyl cellulose sustained release products, including film coated tablets 7, microspheres 8,9, microcapsules 10 and matrix tablets. Example an alkali cellulose is prepared by immersing cellulose in a 60% aqueous solution of sodium hydroxide and pressing the impregnated cellulose until the amount of solution remaining contains a quantity of sodium hydroxide corresponding. The role of surfactants on ethylcellulose oleogel structure and mechanical properties. Ethyl cellulose is soluble in varying amounts in certain organic solvents, depending upon the ethoxyl content. Study of the effect of the plasticizer on the structure and surface characteristics of ethylcellulose free films with ftir spectroscopy. Ec thermal analysis revealed a glass transition at c and a melting temperature at 180 c. Ethyl cellulose ec is regarded as nontoxic, nonallergic, and nonirritating material and has good film forming properties that enable it. Molecular formula ethyl cellulose c 6 h 7 o 2 oc 2 h 5 3 n. Ethyl cellulose is compatible with other cellulose ethers, mineral oils, vegetable oils, most plasticizers, and many natural and synthetic resins.
With 24 wv % ec in ethanol as electrospinnable core fluid and. Sep 10, 2009 ethyl cellulose microcapsules were developed for use as a drugdelivery device for protecting folic acid from release and degradation in the undesirable environmental conditions of the stomach, whilst allowing its release in the intestinal tract to make it available for absorption. Triethyl citrate tec and dibutyl sebacate dbs were the plasticizers used while hydroxypropyl methyl cellulose hpmc was used as the poreformer. Marangoni abstract 4 the characterization of the thermo. Ethyl cellulose prepared at the 26th jecfa 1982, published in fnp 25 1982 and fnp 52 1992. Prepared by treating cotton with an organic solvent to dewax it and removing pectic acids by extration with a solution of sodium hydroxide.
Metals and arsenic specifications revised at the 57th jecfa 2001. Definition ethyl ether of cellulose, prepared from wood pulp or cotton by treatment with alkali and ethylation of the alkali cellulose with ethyl chloride. Ethyl cellulose cas no 9004573 manufacturers, suppliers. Us26044a us752565a us75256547a us26044a us 26044 a us26044 a us 26044a us 752565 a us752565 a us 752565a us 75256547 a us75256547 a us 75256547a us 26044 a us26044 a us 26044a authority us united states prior art keywords ethyl cellulose octyl tertiary diphenyloxide di prior art date 19470604 legal status the legal status is an assumption and is not a. Ethyl hydroxyethyl cellulose ehec is a nonionic watersoluble cellulose ether, today used in a variety of industrial applications, mainly in water based paints and. The objective of present research was to investigate the influence of biofield treatment on physical, chemical and thermal properties of ethyl cellulose ec and methyl cellulose mc. The physical structure and properties of ethylcellulose ec powders of different molecular weights were examined. After over a decade with the organization, she is moving her skillset into the sales and marketing arena as the first point plasticcizer contact for handling and directing product inquiries, working closely with the sales team dia provide support with. Ethyl cellulose ec is a kind of waterinsoluble cellulose ether with favorable mechanical properties, relatively low cost and good filmforming performance.
Ethyl chloride is used in the production of ethyl cellulose, use as a solvent, refrigerant, and topical anesthetic, in the manufacture of dyes, chemicals, and pharmaceuticals, and as a medication to alleviate. Preparation of ethyl cellulose nanoparticles by solventdisplacement using the conventional method and a recirculation system 175 drugs, but holds the appealing potential of being able to transport watersoluble drugs as well. Batch removal of pb ions from aqueous medium using. A full bar means this is the highest value in the relevant.
An aqueous dispersion of ethyl cellulose offers various processing advantages over organic ethyl cellulose solution. Ketoprofenethyl cellulose nanofibers fabricated using an. Aqualon ec can be used to coat one or more active ingredients of a tablet to prevent them from. General properties of methocel cellulose ethers general properties common to the whole family of methocel cellulose ether products are listed below. Skin contact wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes.
The food additive ethyl cellulose may be safely used in food in accordance with the following prescribed conditions. Aqueous solutions of ethyl hydroxyethyl cellulose and hydrophobic modified ethyl hydroxyethyl cellulose polymer. They have outstanding chemical and physical properties table 1. It is prepared from wood pulp or cotton by treatment with alkali and ethylation of the alkali cellulose with ethyl chloride.
The number of ethyl groups can vary depending on the manufacturer. Ethyl hydroxyethyl cellulose ehec in paper coating colors. The study of the incorporation of the plasticizer and the mechanical properties of ethylcellulose free films international conference on biobased polymers and composites 2012. Effect of molecular weight on mechanical properties of films. Ec is prepared by the reaction of ethyl chloride with alkali cellulose. A molecular weight in the range of 20144 kda with a large polydispersity was determined. Ethyl methyl cellulose is a thickener, vegetable gum, foaming agent and emulsifier. A group adi not specified was established at the 35th jecfa 1989. Expired lifetime application number us752565a inventor earle l kropscott jr. The influence of sheath solvent s flow rate on the quality. Adipic acid esters are used as lowtemperatureresistant and lowviscosity plasticizer for pvc and its copolymers and cellulose esters e. Effect of hydroxypropyl methylcellulose and ethyl cellulose. Not combustion, hygroscopicity small, high degree of transparency.
It is available in a variety of grades, which differ in viscosity. White granular solids or fiber, relative density of 1. To print a hardcopy of a pdf file correctly you must have a postscript printer. Hercules company can be divided into three typesk,n,and t. Its e number is e465 chemically, it is a derivative of cellulose with ethyl and methyl groups attached by ether linkages. Antioxidants permitted for use in food may be added for stabilizing purposes. Characterization of physicochemical and thermal properties of. Each model has special grade and quality requirements according to the special uses. Chemically, it is a derivative of cellulose with ethyl and methyl groups attached by ether linkages. Ethyl cellulose microcapsules were developed for use as a drugdelivery device for protecting folic acid from release and degradation in the undesirable environmental conditions of the stomach, whilst allowing its release in the intestinal tract to make it available for absorption. Aqualon ec is soluble in a wide range of organic solvents. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.
Ethyl cellulose article about ethyl cellulose by the free. For more specific values, follow the links immediately below. Both samples were characterized using contact angle analysis, n 2 adsorptiondesorption technique, ftir and sem. This study also investigated the effects of different types of plasticizers on the properties and stability of the films exposed to different storage conditions and attempted to elucidate the mechanism for the changes observed.
Cellulose and its derivatives are used as potential matrices for biomaterials and tissue engineering applications. The biopolymer composing the cell wall of vegetable tissues. Ethylcellulose is used in pharmaceutical industry as a coating agent, flavoring fixative, tablet binder and filler, and as a viscosityincreasing agent. Product safety assessment ethocel ethylcellulose polymers. Dasbach the dow chemical company, midland, michigan 48674, usa introduction ethylcellulose ec is a waterinsoluble polymer, which has been used successfully for coating applications in drug delivery with. Ethyl cellulose is a thermoplastic, further classified as a cellulosic plastic. Ethyl cellulose ec is an inert, biocompatible, nonionic water insoluble polymer widely used to prepare slowrelease formulations of drugs due to its controlled release property 4. The principal fiber composing the cell wall of vegetable tissues wood, cotton, flax, grass, etc. Ethyl hydroxyethyl cellulose ehec in paper coating. Bacterial translocation and intestinal capillary permeability following major liver resection in the rat. It can be prepared by treatment of cellulose with dimethyl sulfate and ethyl chloride in the presence of an alkali see also. Ec displays a variety of properties, allowing it to be used in a wide range of.
December 5, 2014 the dow chemical company page 2 of 7 ethylcellulose polymers are used in a variety of pharmaceuticals, personal care products, foods, ceramics, pastes, inks, and specialty coatings. The graph bars on the material properties cards below compare grade 1 ec to. The drugpolymer mixture was mixed well and then slowly emulsified into 100 ml of paraffin oil that contained 1 ml of span 80 as an emulsifier. The article of commerce can be specified further by viscosity. It has the highest strength compared to the other variants of ethyl cellulose. Ethylcellulose polymers have been approved by the eu in food applications since the end of. These properties make them useful in many applicationsfrom pharmaceutical, food, and personal care applications to specialty applications, including some of. Aqualon ethylcellulose ec is a cellulose ether distinguished by its versatility.
Us26044a ethyl cellulose composition containing di. With ethyl cellulose ec and ketoprofen ket as the filamentforming matrix and the active pharmaceutical ingredient, drugloaded composite nanofibers are generated smoothly and continuously with few user interventions. Ethyl cellulose microcapsules for protecting and controlled. It is mainly used as a thinfilm coating material for coating paper, vitamin and medical pills, and for. The chemical research laboratories of polaroid corporation, cambridge, massachusetts received february 14, 1952 introduction during a research program designed to study and compare the low temperature strength properties of films of various cellulosic derivatives, it was found necessary to. Ethyl cellulose general information, process, products. Typically, aqualon ec is used as a nonswellable, insoluble component in matrix or coating systems.
Some properties of ethyl cellulose films1 howard c. The furosemide containing hydroxypropyl cellulose gel and ethylenevinyl acetate matrix for transdermal delivery purposes has been reported. The properties of ethyl cellulose include eleven common variations. Ethyl cellulose aqueous dispersion provides a stable, reproducible, phindependent drugrelease profile with similar dissolution profiles in both fed and fasted states 2. Preparation of ethyl cellulose nanoparticles by solvent. The ethyl cellulose capsules contained a large number of mechanically made micropores 400. Ethyl acetate is used as a solvent in the manufacture of modified hop extract and decaffeinated tea or. Application of ethylcellulose coating to hydrophilic. An aqueous dispersion of ethyl cellulose offers various processing advantages over organic ethyl cellulose solution, including reduced coating processing time higher solid content and low viscosity, avoidance of potential toxicity due to residual solvent, and reduced environmental concerns, chokshi told pharmaceutical technology. Influence of storage conditions and type of plasticizers on. Ethyl acetate is found in cereal crops, radishes, fruit juices, beer, wine, spirits etc. For indirect food use such as in paper and paperboard that might contact food, ethyl cellulose is considered generally recognized as safe gras by the u. The present research investigates the influence of sheath solvents flow rate on the quality of electrospun ethyl cellulose ec nanofibers using a modified coaxial process.
Ethyl cellulose ec is a partly oethylated cellulose ether derivative. Ethyl cellulose ec is a nontoxic, stable, compressible, inert, hydrophobic polymer that has been widely used to prepare pharmaceutical dosage forms. Ethyl cellulose, ethoxyl content 50%, 100 cps revision date 19jan2018 ethylcellulose 9004573 48 4. Fieldemission scanning electron microscopic observations demonstrated that the composite nanofibers prepared using. In order to protect core substances and achieve sustainable drug release, ec is widely used as coating agent and encapsulation in pharmaceuticals murtaza, 2012, sogol and ismaeil, 2011. Firstaid measures eye contact rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Us2605328a us87579a us8757949a us2605328a us 2605328 a us2605328 a us 2605328a us 87579 a us87579 a us 87579a us 8757949 a us8757949 a us 8757949a us 2605328 a us2605328 a us 2605328a authority us united states prior art keywords adhesive coating ethyl cellulose terphenyl cellulose prior art date 19490414 legal status the legal status is an assumption and is not a legal. The influence of sheath solvent s flow rate on the quality of. Ga is a watersoluble molecule comprised of a hydrophilic part two moieties of glucuronic acid and a hydrophobic frag. Amorphous ethyl cellulose ec of varying viscosities 10, 22, and 300 cp were obtained from aldrich ec 10 and ec 22 and dow chemical ethocel 300 with ethoxyl content of 48%, a product commonly derived from cellulose by etheration 48.
Due to the poor compression characteristics of the api a commercially available direct. Effects of plasticizers, additives, and solvents karen a. Identification product name ethyl cellulose, ethoxyl. The in vitro evaluation of ec microcapsules have elucidated that their particle characteristics are very useful to control drug release behavior. A process for the manufacture of organosoluble ethyl cellulose which comprises providing an alkali cellulose containing from 0. In this study, ethyl cellulose and gammaal 2 o 3 nanoparticlesethyl cellulose electrospun adsorbents were prepared for the batch removal of pb ii ions from aqueous solution. Its use is presently requested in the formulation of food supplements in dry applications e.
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